Ryan Kalkbrenner collected 25 points and 13 rebounds as Creighton continued its dominance of DePaul with a 75-65 victory on Wednesday night in Omaha, Neb.Kalkbrenner made 12 of 17 shots from the floor for the Bluejays (20-8, 13-4 Big East), who recorded their 22nd consecutive win over the Blue Demons and 27th in their last 28 meetings.Creighton, which posted a 73-49 victory over DePaul on Jan. 21, reached the 20-win plateau for the 10th straight season. The Bluejays shot a robust 51.8 percent from the floor on Wednesday, held a 42-22 edge in rebounds and a 36-26 advantage in points in the paint.Steven Ashworth drained four 3-pointers and finished with 16 points. He also had six assists, and Fedor Zugic added nine points off the bench for Creighton, which scored 15 straight points midway through the second half to effectively put the game away.Isaiah Rivera collected 18 points and eight rebounds and CJ Gunn had 14 points for the Blue Demons (11-18, 2-16), who have lost six in a row and 14 of their last 16 games.DePaul played without leading rebounder NJ Benson (hand) and fellow forward David Skogman (undisclosed).